Abstract

Objective: To compare the efficacy of ciprofloxacin with ceftriaxone in the treatment of spontaneous bacterial peritonitis inpatients with cirrhosis liver and ascites. Design: This hospital based quasi-experimental study. Setting: Department of Medicine, KhyberTeaching Hospital Peshawar. Period: October, 2009 to April, 2010. Material and Methods: A total of 200 patients were selected by nonprobabilitypurposive sampling method after obtaining an informed consent. Sample size was calculated through WHO statistical calculator. Allthe selected patients had clinical and biochemical evidence of cirrhosis liver and spontaneous bacterial peritonitis. Both sexes were included inthe study. They were randomly divided into two groups; group I was treated with ciprofloxacin and group II was treated with ceftriaxone.Results: 200 patients including 124 males and 76 females with spontaneous bacterial peritonitis were included in the study. 100 patients eachwere treated with ciprofloxacin and ceftriaxone in the two groups. 82% responded favourably to 5 days course of I/V 200mg ciprofloxacin and91% were cured with 5 days therapy of I/V 2gm ceftriaxone. Conclusions: Both ceftriaxone and ciprofloxacin are equally effective in thetreatment of spontaneous bacterial peritonitis.